With the continuous improvement in lightning observation method and instrument, lightning detection and location data are substantially improved in quality and have found wide applications. As a powerful formal language, regular expression has been extensively applied to process original lightning detection and location data, from data compilation and storage to data analysis and query. The regular expression can simplify the processing procedures and improve working efficiencies in data processing of lightning detection and location system. This paper introduces the application of C# based regular expression in lightning detection and location data processing on the. Net platform.