Cyclic peptide is obtained by the dehydration and condensation of one free N-terminus α-amino group and another free C-terminal α-carboxy group of the peptide,with a lot of biological activities such as anti-tumor,anti-HIV,antibacterial,antimalarial and so on.So,we believe the cyclic peptide will have a wide application prospect in many fields including biochemistry,materials,environmental protection and especially the medicine.In a whole chemical reaction,the reactant is connected to the solid phase and participates in a reaction vessel,which we call a solid-phase synthesis.The synthesis method is convenient for automatic operation,high in yield and easy to separate the product.In this paper,the principle,steps of the solid-phase synthesis and factors influencing the cyclization of cyclic peptide were reviewed.