Power grid is an important factor in the development of distributed energy,so the research on the relationship between them is very necessary.If Win-Win cooperation for power supply in the region can be achieved,it will provide an effective way to relieve the energy crisis and the pressure of power supply.In this paper,distributed energy systems and power grid in a certain region are Abstracted as two types of Agent by using the approach of Agent modeling.The model of regional cooperation is established to simulate the decision-making behavior with the guidance of expected annual profit.By the iterative process of "adjusting the strategy and calculating the profit ",the simulation illustrates the boundary conditions and the adjustment track of win-win cooperation.Finally an example of the Energy Center of Shanghai Pudong International Airport is put forward to prove the effectiveness of the method.